Learning Module Overview for:
Mechanisms of Action of Antifungal Agents

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Release date: September 30, 2008
Expiration date: September 30, 2009

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Accreditation
This learning activity has been designated to a maximum of 0.50 AMA PRA Category 1 Credits™. Physicians should only claim credit commensurate with the extent of their participation in this activity.

Target Audience
This learning activity is intended for oncologists, hematologists, infectious disease specialists who treat transplant patients and other patient populations at risk for developing fungal infections.

Learning Objectives
After completing this educational activity, the learner should be better able to:
  • Understand the general structure of fungi and the potential targets for antifungal agents
  • Understand the mechanism of action of antifungal agents
  • Recognize the spectrum of activity of different antifungal agents
  • Understand the mechanism of resistance of antifungal agents
  • Understand the general concepts and limitations of in vitro susceptibility testing of antifungal agents
Authors
Tony Mazzulli, MD, FRCPC, FACP
Professor
University of Toronto
Deputy Chief Microbiologist & Infectious Diseases Specialist
Mount Sinai Hospital
Toronto, Ontario

David A. Stevens, MD, FACP
Professor of Medicine
Stanford University Medical School
Chief, Infectious Diseases
Santa Clara Valley Medical Center
San Jose, California

Medical Writer
Laurel McKee Ranger
Randolph, NJ

Disclosure of Financial Interests
As an accredited provider of continuing medical education, Imedex, LLC is required to ask authors to disclose any real or apparent conflict of interest they may have as related to the content of their chapter(s). The existence of commercial or financial interests of speakers related to the subject matter of their chapter(s) should not be construed as implying bias or decreasing the value of their chapter(s). However, the disclosure should help participants form their own judgments.
All authors were independently selected by the organizing committee. Those authors who disclosed affiliations or financial interests with the commercial organizations involved with products, to which the may refer are listed below.

1 = grant research
2 = consultant
3 = speaker’s bureau
4 = stock shareholder
5 = other support

Dr Tony Mazzulli
Supporters of this activity:
Pfizer Inc3

Other affiliations:
Schering-Plough2,3

Dr David A. Stevens
Supporters of this activity:
Astellas Pharma US, Inc.3
Pfizer Inc3

Other affiliations:
Enzon Inc.3
Gilead Sciences, Inc.3
Johnson & Johnson3
Schering-Plough3

Medical Writer
Laurel McKee Ranger
Does not report any affiliations with commercial organizations.

Imedex, LLC Staff Disclosure of Financial Relationships
Imedex, LLC is a subsidiary of AmerisourceBergen Specialty Group, which is a subsidiary of AmerisourceBergen Company. All Imedex staff members, except for the following, who are in a position to control the content of this activity, have no financial relationships with any commercial interests that are relevant to this activity:

Keith Steward, MD, MBA, owns shares of Pfizer Inc and Johnson & Johnson, as well as stock options for AmerisourceBergen.

Chris Bolwell owns shares of GlaxoSmithKline and stock options for AmerisourceBergen.

Bradley Bongiovanni, ND, Becky Lynch, RN, Emily Geiger, and Don Harting, MA, ELS own stock options for AmerisourceBergen.

Imedex, LLC is an independent provider of continuing medical education. Imedex, LLC has no proprietary or financial interest in medical or healthcare products over which the FDA has regulatory authority.

Disclosure of Unapproved Uses and Investigational Drugs
This activity may contain information about experimental and other uses of drugs or devices that are not currently approved by the US Food and Drug Administration (FDA) and/or other national regulatory agencies in the United States and other countries. Participants in the United States are encouraged to consult the FDA-approved product labeling for any drug or device mentioned in this program before use. Participants from other countries should consult with their respective regulatory authorities.

Statement of Commercial Support
The following companies have provided unrestricted educational grants in support of this activity: Astellas Pharma US, Inc. and Pfizer Inc.





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